{"id":3380,"date":"2024-09-22T07:40:43","date_gmt":"2024-09-22T06:40:43","guid":{"rendered":"https:\/\/www.forethoughtmed.com\/?p=3380"},"modified":"2024-09-20T14:18:24","modified_gmt":"2024-09-20T13:18:24","slug":"is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis","status":"publish","type":"post","link":"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/","title":{"rendered":"\u810a\u67f1\u5074\u6e7e\u75c7\u306f\u907a\u4f1d\u3059\u308b\u306e\u304b\uff1f\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3092\u63a2\u308b"},"content":{"rendered":"<p>\u810a\u67f1\u5074\u6e7e\u75c7\u306f\u3001\u80cc\u9aa8\u306e\u7570\u5e38\u306a\u6e7e\u66f2\u3092\u7279\u5fb4\u3068\u3059\u308b\u75c5\u72b6\u3067\u3042\u308b\u3002\u4eba\u53e3\u306e\u7d042-3%\u304c\u7f79\u60a3\u3057\u3001\u305d\u306e\u7a0b\u5ea6\u306f\u69d8\u3005\u3067\u3042\u308b\u3002\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u6b63\u78ba\u306a\u539f\u56e0\u306f\u307e\u3060\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u907a\u4f1d\u7684\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u8a3c\u62e0\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u3068\u3001\u907a\u4f1d\u3068\u3053\u306e\u75c7\u72b6\u3068\u306e\u9593\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u63a2\u308a\u307e\u3059\u3002<\/p><figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"396\" height=\"335\" src=\"http:\/\/www.forethoughtmed.com\/wp-content\/uploads\/2024\/08\/gr2-207.jpg\" alt=\"\u653e\u5c04\u7dda\u306b\u3088\u308b\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u89e3\u91c8\" class=\"wp-image-5173\" style=\"width:840px;height:auto\" srcset=\"http:\/\/www.forethoughtmed.com\/wp-content\/uploads\/2024\/08\/gr2-207.jpg 396w, http:\/\/www.forethoughtmed.com\/wp-content\/uploads\/2024\/08\/gr2-207-14x12.jpg 14w\" sizes=\"(max-width: 396px) 100vw, 396px\" \/><\/figure><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_74 counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"\u30c8\u30b0\u30eb\u76ee\u6b21\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">\u30c8\u30b0\u30eb<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Understanding_the_Difference_Between_Hereditary_and_Genetic_Factors\" >\u907a\u4f1d\u7684\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u9055\u3044\u3092\u7406\u89e3\u3059\u308b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Genetic_Factors_Associated_with_Scoliosis\" >\u810a\u67f1\u5074\u6e7e\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Role_of_Genetic_Mutations_in_Scoliosis_Development\" >\u810a\u67f1\u5074\u6e7e\u75c7\u767a\u75c7\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u5909\u7570\u306e\u5f79\u5272<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Genetic_Testing_for_Scoliosis\" >\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Identifying_Genetic_Markers_for_Scoliosis\" >\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u907a\u4f1d\u7684\u30de\u30fc\u30ab\u30fc\u306e\u540c\u5b9a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Genetic_Variants_and_Scoliosis_Risk\" >\u907a\u4f1d\u5b50\u5909\u7570\u3068\u810a\u67f1\u5074\u6e7e\u75c7\u30ea\u30b9\u30af<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Genetic_Linkages_and_Scoliosis\" >\u907a\u4f1d\u7684\u95a2\u9023\u3068\u810a\u67f1\u5074\u6e7e\u75c7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Genetic_Studies_on_Scoliosis\" >\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u5b66\u7684\u7814\u7a76<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Familial_Patterns_of_Scoliosis\" >\u5074\u6e7e\u75c7\u306e\u5bb6\u65cf\u6027\u30d1\u30bf\u30fc\u30f3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Genetic_Counseling_for_Scoliosis\" >\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#Conclusion_The_Complex_Interplay_of_Genetics_in_Scoliosis\" >\u7d50\u8ad6\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u304a\u3051\u308b\u907a\u4f1d\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"http:\/\/www.forethoughtmed.com\/ja\/is-scoliosis-hereditary-or-genetic-delving-into-the-genetic-factors-behind-scoliosis\/#References\" >\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Understanding_the_Difference_Between_Hereditary_and_Genetic_Factors\"><\/span>\u907a\u4f1d\u7684\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u9055\u3044\u3092\u7406\u89e3\u3059\u308b<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3092\u6398\u308a\u4e0b\u3052\u308b\u524d\u306b\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u9055\u3044\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u907a\u4f1d\u7684\u8981\u56e0\u3068\u306f\u3001\u907a\u4f1d\u5b50\u3092\u4ecb\u3057\u3066\u4e16\u4ee3\u304b\u3089\u4e16\u4ee3\u3078\u3068\u53d7\u3051\u7d99\u304c\u308c\u308b\u5f62\u8cea\u3084\u72b6\u614b\u3092\u6307\u3059\u3002\u4e00\u65b9\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u306f\u3001\u907a\u4f1d\u3057\u305f\u5f62\u8cea\u3068\u81ea\u7136\u306b\u8d77\u3053\u308b\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u306e\u4e21\u65b9\u3092\u542b\u3080\u3001\u3088\u308a\u5e83\u3044\u7bc4\u56f2\u306e\u5f71\u97ff\u3092\u542b\u3080\u3082\u306e\u3067\u3042\u308b\u3002<\/p><figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"474\" height=\"307\" src=\"http:\/\/www.forethoughtmed.com\/wp-content\/uploads\/2024\/08\/OIP-C-14-2.jpg\" alt=\"\" class=\"wp-image-4574\" style=\"width:840px;height:auto\"\/><\/figure><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Genetic_Factors_Associated_with_Scoliosis\"><\/span>\u810a\u67f1\u5074\u6e7e\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u7d20\u304c\u5f37\u3044\u3053\u3068\u304c\u591a\u304f\u306e\u7814\u7a76\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u5bb6\u65cf\u8abf\u67fb\u3084\u53cc\u751f\u5150\u8abf\u67fb\u3067\u306f\u3001\u5bb6\u65cf\u306b\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u75c5\u6b74\u304c\u3042\u308b\u4eba\u307b\u3069\u3001\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u810a\u67f1\u5074\u6e7e\u75c7\u306b\u306a\u308a\u3084\u3059\u3044\u4f53\u8cea\u306b\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Role_of_Genetic_Mutations_in_Scoliosis_Development\"><\/span>\u810a\u67f1\u5074\u6e7e\u75c7\u767a\u75c7\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u5909\u7570\u306e\u5f79\u5272<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u3082\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002TBX6\u907a\u4f1d\u5b50\u306e\u3088\u3046\u306a\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u304c\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u810a\u690e\u306e\u6b63\u5e38\u306a\u767a\u80b2\u3092\u59a8\u3052\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u898b\u3089\u308c\u308b\u7279\u5fb4\u7684\u306a\u6e7e\u66f2\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u3060\u3051\u304c\u5074\u5f2f\u75c7\u306e\u539f\u56e0\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Genetic_Testing_for_Scoliosis\"><\/span>\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u5b50\u691c\u67fb<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u8a3a\u65ad\u3068\u7ba1\u7406\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u624b\u6bb5\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u3053\u308c\u306f\u3001\u500b\u4eba\u306eDNA\u3092\u5206\u6790\u3057\u3001\u810a\u67f1\u5074\u6e7e\u75c7\u306b\u95a2\u9023\u3059\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3084\u7a81\u7136\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u306e\u60c5\u5831\u306f\u3001\u533b\u7642\u5c02\u9580\u5bb6\u304c\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5224\u65ad\u3057\u3001\u6cbb\u7642\u3092\u6c7a\u5b9a\u3059\u308b\u969b\u306e\u6307\u91dd\u3068\u306a\u308a\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u6839\u672c\u7684\u306a\u907a\u4f1d\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u8cb4\u91cd\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3059\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Identifying_Genetic_Markers_for_Scoliosis\"><\/span>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u907a\u4f1d\u7684\u30de\u30fc\u30ab\u30fc\u306e\u540c\u5b9a<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3067\u304d\u308b\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc\u3092\u7a4d\u6975\u7684\u306b\u63a2\u3057\u3066\u3044\u308b\u3002\u810a\u67f1\u5074\u5f2f\u75c7\u60a3\u8005\u306eDNA\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u79d1\u5b66\u8005\u305f\u3061\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u3057\u3084\u3059\u3055\u306b\u95a2\u9023\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc\u3092\u540c\u5b9a\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30de\u30fc\u30ab\u30fc\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u5229\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u65e9\u671f\u4ecb\u5165\u3084\u4e88\u9632\u63aa\u7f6e\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Genetic_Variants_and_Scoliosis_Risk\"><\/span>\u907a\u4f1d\u5b50\u5909\u7570\u3068\u810a\u67f1\u5074\u6e7e\u75c7\u30ea\u30b9\u30af<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u907a\u4f1d\u30de\u30fc\u30ab\u30fc\u306b\u52a0\u3048\u3066\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3082\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001GPR126\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u5f62\u614b\u3067\u3042\u308b\u601d\u6625\u671f\u7279\u767a\u6027\u810a\u67f1\u5074\u5f2f\u75c7\uff08AIS\uff09\u306e\u9ad8\u3044\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u6839\u5e95\u306b\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5bfe\u3059\u308b\u8cb4\u91cd\u306a\u6d1e\u5bdf\u3092\u3082\u305f\u3089\u3057\u3001\u6a19\u7684\u6cbb\u7642\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Genetic_Linkages_and_Scoliosis\"><\/span>\u907a\u4f1d\u7684\u95a2\u9023\u3068\u810a\u67f1\u5074\u6e7e\u75c7<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u907a\u4f1d\u7684\u9023\u9396\u3068\u306f\u3001\u7279\u5b9a\u306e\u5f62\u8cea\u3084\u72b6\u614b\u306b\u95a2\u9023\u3059\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3084\u30b2\u30ce\u30e0\u306e\u9818\u57df\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u810a\u67f1\u5074\u5f2f\u75c7\u3068\u306e\u95a2\u9023\u3067\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u7684\u9023\u9396\u304c\u540c\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u306b\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u9023\u9396\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u5bc4\u4e0e\u3059\u308b\u907a\u4f1d\u7684\u7d4c\u8def\u3084\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u3059\u308b\u624b\u304c\u304b\u308a\u3092\u63d0\u4f9b\u3057\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u3084\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3078\u306e\u9053\u3092\u958b\u304f\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Genetic_Studies_on_Scoliosis\"><\/span>\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u5b66\u7684\u7814\u7a76<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u8907\u96d1\u306a\u907a\u4f1d\u7684\u57fa\u76e4\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u3001\u6570\u591a\u304f\u306e\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u304d\u305f\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u3067\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u60a3\u8005\u306eDNA\u3092\u5206\u6790\u3057\u3001\u7f79\u60a3\u3057\u3066\u3044\u306a\u3044\u4eba\u306eDNA\u3068\u6bd4\u8f03\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u3092\u901a\u3057\u3066\u3001\u7814\u7a76\u8005\u306f\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u95a2\u9023\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u3084\u907a\u4f1d\u5b50\u5909\u7570\u3092\u540c\u5b9a\u3057\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u6839\u672c\u7684\u306a\u907a\u4f1d\u7684\u8981\u56e0\u306b\u5149\u3092\u5f53\u3066\u3066\u3044\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Familial_Patterns_of_Scoliosis\"><\/span>\u5074\u6e7e\u75c7\u306e\u5bb6\u65cf\u6027\u30d1\u30bf\u30fc\u30f3<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u5bb6\u65cf\u6027\u30d1\u30bf\u30fc\u30f3\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3053\u3068\u3067\u3001\u3053\u306e\u75be\u60a3\u306e\u907a\u4f1d\u7684\u8981\u7d20\u304c\u3055\u3089\u306b\u8a3c\u660e\u3055\u308c\u305f\u3002\u5074\u5f2f\u75c7\u306e\u5bb6\u65cf\u6b74\u306e\u3042\u308b\u4eba\u306f\u3001\u5074\u5f2f\u75c7\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u304c\u3042\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5bb6\u65cf\u5185\u3067\u53d7\u3051\u7d99\u304c\u308c\u3001\u810a\u67f1\u5074\u6e7e\u75c7\u306b\u306a\u308a\u3084\u3059\u3044\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Genetic_Counseling_for_Scoliosis\"><\/span>\u810a\u67f1\u5074\u6e7e\u75c7\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u907a\u4f1d\u7684\u8981\u7d20\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306f\u810a\u67f1\u5074\u5f2f\u75c7\u7ba1\u7406\u306e\u91cd\u8981\u306a\u5074\u9762\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u500b\u4eba\u3068\u5bb6\u65cf\u306b\u63d0\u4f9b\u3057\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u4e88\u9632\u7b56\u3084\u6cbb\u7642\u6cd5\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c0\u30f3\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306f\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u60a3\u8005\u3055\u3093\u304c\u3001\u81ea\u5206\u306e\u5065\u5eb7\u7ba1\u7406\u306b\u3064\u3044\u3066\u5341\u5206\u306a\u60c5\u5831\u3092\u5f97\u305f\u4e0a\u3067\u6c7a\u65ad\u3092\u4e0b\u3057\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u306a\u308b\u307e\u3067\u306e\u9053\u306e\u308a\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u304f\u308c\u307e\u3059\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion_The_Complex_Interplay_of_Genetics_in_Scoliosis\"><\/span>\u7d50\u8ad6\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u304a\u3051\u308b\u907a\u4f1d\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h2><p>\u7d50\u8ad6\u3068\u3057\u3066\u3001\u810a\u67f1\u5074\u6e7e\u75c7\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u4e21\u65b9\u304c\u95a2\u4e0e\u3059\u308b\u8907\u96d1\u306a\u75be\u60a3\u3067\u3042\u308b\u3002\u907a\u4f1d\u7684\u8981\u56e0\u306f\u5074\u6e7e\u75c7\u306b\u898b\u3089\u308c\u308b\u5bb6\u65cf\u6027\u306e\u30d1\u30bf\u30fc\u30f3\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u304c\u3001\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u3084\u5909\u7570\u4f53\u3082\u5074\u6e7e\u75c7\u306e\u767a\u75c7\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u7814\u7a76\u306b\u3088\u308a\u3001\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u907a\u4f1d\u7684\u57fa\u76e4\u306b\u95a2\u3059\u308b\u8cb4\u91cd\u306a\u6d1e\u5bdf\u304c\u5f97\u3089\u308c\u3001\u65e9\u671f\u767a\u898b\u3001\u500b\u5225\u5316\u6cbb\u7642\u3001\u6cbb\u7642\u306e\u9032\u6b69\u306e\u53ef\u80fd\u6027\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u80cc\u5f8c\u306b\u3042\u308b\u907a\u4f1d\u7684\u8981\u56e0\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u3001\u305d\u306e\u4e88\u9632\u3068\u7ba1\u7406\u306e\u3088\u308a\u52b9\u679c\u7684\u306a\u6226\u7565\u3092\u958b\u767a\u3057\u7d9a\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p><h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"References\"><\/span>\u53c2\u8003\u6587\u732e<span class=\"ez-toc-section-end\"><\/span><\/h2><ol class=\"wp-block-list\"><li>BNC2\u306e\u6a5f\u80fd\u7684SNP\u306f\u601d\u6625\u671f\u7279\u767a\u6027\u5074\u5f2f\u75c7\u3068\u95a2\u9023\u3059\u308b\". <em>\u30cd\u30a4\u30c1\u30e3\u30fc\u30fb\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u30ba<\/em>.2015;6:6682\uff1a <a>10.1038\/ncomms7682<\/a>.<\/li>\n\n<li>Sharma S, Gao X, Londono D, et al. \"Genome-wide association studies of adolescent idiopathic scoliosis suggest candidates susceptibility genes.\". <em>\u30d2\u30c8\u5206\u5b50\u907a\u4f1d\u5b66<\/em>.2011;20(7):1456-1466\uff1a <a>10.1093\/hmg\/ddr017<\/a>.<\/li>\n\n<li>Patten SA, Margaritte-Jeannin P, Bernard JC, et al. \"Functional variants of PAX1 gene in adolescent idiopathic scoliosis.\". <em>\u80cc\u9aa8<\/em>.2015;40(11):918-926\uff1a <a>10.1097\/BRS.0000000000000916<\/a>.<\/li>\n\n<li>Kou I, Takahashi Y, Johnson TA, et al. \"Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.\". <em>\u30cd\u30a4\u30c1\u30e3\u30fc\u30fb\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/em>.2013;45(6):676-679\uff1a <a>10.1038\/ng.2639<\/a>.<\/li>\n\n<li>Baschal EE, Wethey CI, Swindle K, et al. \"Exome sequencing identifies a rare variant in fibrillin-1 (FBN1) gene associated with familial scoliosis.\". <em>G3: \u907a\u4f1d\u5b50\u3001\u30b2\u30ce\u30e0\u3001\u907a\u4f1d\u5b66<\/em>.2014;4(6):1171-1177\uff1a <a>10.1534\/g3.114.010009<\/a>.<\/li>\n\n<li>Xu L, Sun X, Huang S, et al. \"The genetic basis of adolescent idiopathic scoliosis.\". <em>\u5c0f\u5150\u79d1\u5b66\u306e\u6700\u524d\u7dda<\/em>.2021;9:574574\uff1a <a>10.3389\/fped.2021.574574<\/a>.<\/li>\n\n<li>Zhu Z, Tang NL, Xu L, et al. \"Genome-wide association study identifies novel susceptibility loci for adolescent idiopathic scoliosis in Han Chinese population.\". <em>\u30cd\u30a4\u30c1\u30e3\u30fc\u30fb\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u30ba<\/em>.2015;6:8355\uff1a <a>10.1038\/ncomms9355<\/a>.<\/li>\n\n<li>\u30df\u30e9\u30fcNH.\u300c\u601d\u6625\u671f\u7279\u767a\u6027\u5074\u5f2f\u75c7\u306e\u539f\u56e0\u3068\u81ea\u7136\u53f2\u300d\u3002 <em>\u5317\u7c73\u6574\u5f62\u5916\u79d1\u30af\u30ea\u30cb\u30c3\u30af<\/em>.1999;30(3):343-352\uff1a <a>10.1016\/S0030-5898(05)70095-0<\/a>.<\/li>\n\n<li>Qiu XS, Lv F, Zhu ZZ, et al. \"A novel susceptibility locus for adolescent idiopathic scoliosis at 1p36.3\". <em>\u533b\u5b66\u907a\u4f1d\u5b66\u96d1\u8a8c<\/em>.2014;51(1):23-29\uff1a <a>10.1136\/jmedgenet-2013-101785<\/a>.<\/li>\n\n<li>Tang NL, Yi L, Ma SL, et al. \"A relook into association of MATN1, LBX1, and GPR126 polymorphisms with AIS susceptibility in Hong Kong Southern Chinese population.\". <em>\u80cc\u9aa8<\/em>.2017;42(12):930-936\uff1a <a>10.1097\/BRS.0000000000001936<\/a>.<\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>\u810a\u67f1\u5074\u5f2f\u75c7\u306e\u771f\u5b9f\u3092\u77e5\u308b\uff1a\u907a\u4f1d\u6027\u304b\u3001\u907a\u4f1d\u6027\u304b\uff1f\u810a\u67f1\u5074\u5f2f\u75c7\u306b\u5f71\u97ff\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u3087\u3046\u3002<\/p>","protected":false},"author":5,"featured_media":5360,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/posts\/3380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/comments?post=3380"}],"version-history":[{"count":4,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/posts\/3380\/revisions"}],"predecessor-version":[{"id":5362,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/posts\/3380\/revisions\/5362"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/media\/5360"}],"wp:attachment":[{"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/media?parent=3380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/categories?post=3380"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.forethoughtmed.com\/ja\/wp-json\/wp\/v2\/tags?post=3380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}